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The Cancer Research UK Manchester Institute (CRUK MI), affiliated with The University of Manchester, has announced several new job openings for ambitious researchers looking to contribute to cutting-edge cancer research. These positions offer an excellent opportunity to work at a world-renowned institute with state-of-the-art facilities. Below are the available positions, their details, and application guidelines.

1. Senior Scientific Officer – RNA Dynamics in Cancer (Job Ref: MI/24/46)

  • Role Overview: The Senior Scientific Officer (SSO) will join the RNA Dynamics in Cancer research group. This multifaceted role involves overseeing in vivo and in vitro experiments, managing laboratory operations, and supporting the principal investigator in executing cancer research projects.

  • Key Responsibilities:

    • Design and perform in vivo experiments.
    • Manage daily lab operations and maintain equipment.
    • Conduct research projects focused on identifying novel targets in malignant breast cancer.
    • Provide training and guidance to team members on experimental procedures.
  • Requirements:

    • A BSc in Biochemistry, Molecular Biology, or related discipline.
    • Experience in managing scientific research projects, ideally with a focus on RNA biology.
    • Previous experience with in vivo models and a valid Personal Licence (PIL A & B).
  • Salary: £28,344 – £45,357 per annum.

  • Duration: Permanent role.

  • Application Deadline: Applications may close earlier if there is a high volume of applicants.

  • Contact: Informal inquiries can be made to Sylvain Delaunay at sylvain.delaunay@cruk.manchester.ac.uk.


2. Principal Computational Biologist – National Biomarker Centre (Job Ref: MI/24/45_2)

  • Role Overview: The Principal Computational Biologist will lead efforts in optimising the development of the CUPiD classifier for detecting the tissue-of-origin (TOO) of cancers using machine learning models on cell-free DNA (cfDNA) methylation profiles.

  • Key Responsibilities:

    • Develop machine learning models and integrate multi-omic data for improved cancer classification.
    • Collaborate with a multidisciplinary team, including clinicians and bioinformaticians.
    • Contribute to the validation of the classifier in a large cohort of patient samples.
  • Requirements:

    • PhD in Computational Biology, Bioinformatics, or a related field.
    • Extensive experience in machine learning, data analysis, and bioinformatics.
    • Proficiency in R, Python, and handling high-throughput sequencing data.
  • Salary: £38,000 – £45,000 per annum.

  • Duration: Fixed term until August 2027.

  • Contact: Informal inquiries can be directed to Dr. Alex Clipson at alexandra.clipson@cruk.manchester.ac.uk.


3. Postdoctoral Scientist – Cancer Immunosurveillance Group (Job Ref: MI/24/54)

  • Role Overview: The Postdoctoral Scientist will focus on investigating the interactions between the host, microbiome, and nutrient availability that influence cancer immunity. The position involves working with in vivo mouse models, organoids, and human samples to identify key factors in microbiome-dependent cancer immunity.

  • Key Responsibilities:

    • Perform experiments using flow cytometry, RNA sequencing, and metabolomics.
    • Design and execute studies related to nutrient-microbiome interactions in cancer development.
    • Collaborate with cross-disciplinary teams and present findings at national and international conferences.
  • Requirements:

    • PhD in Immunology, Microbiology, or related discipline with experience in host-microbiome interactions.
    • Proficiency in single-cell RNA sequencing, confocal microscopy, and data analysis using R or Python.
    • Strong publication record and experience in cancer biology research.
  • Salary: £32,868 – £42,717 per annum.

  • Duration: Up to 4 years, with potential extension to 7 years based on performance.

  • Contact: Informal inquiries can be made to Dr. Evangelos Giampazolias at evangelos.giampazolias@cruk.manchester.ac.uk.


4. Research Associate – Biomarker Research Unit (Job Ref: MI/24/57)

  • Location: Cancer Research UK Manchester Institute, Manchester, UK
  • Position Type: Full-time, Fixed-term
  • Job Profile: The Research Associate will work within the Biomarker Research Unit (BRU), focusing on the discovery and validation of novel biomarkers for early cancer detection and monitoring. The role involves collaboration with clinical partners to integrate biomarker findings into clinical trials.
  • Key Responsibilities:
    • Conduct biomarker discovery research using high-throughput proteomics and metabolomics.
    • Analyze data from patient samples and validate findings using ELISA and mass spectrometry.
    • Publish results in high-impact journals and contribute to grant applications.
  • Eligibility Requirements:
    • Master’s degree or PhD in Molecular Biology, Biochemistry, or related fields.
    • Experience in biomarker discovery and data analysis.
    • Proficiency in proteomics, bioinformatics, and clinical sample handling.
  • Salary: £35,000 – £45,000 per annum.
  • Contract Duration: 3 years, with potential for renewal.
  • Application Deadline: January 10, 2025.
  • Contact: For more information, contact the Biomarker Research Unit at BRU@cruk.manchester.ac.uk.

5. Principal Investigator – Cancer Genomics (Job Ref: MI/24/57_2)

  • Location: Cancer Research UK Manchester Institute, Manchester, UK
  • Position Type: Full-time, Permanent
  • Job Profile: The Principal Investigator will lead a new research group within the Cancer Genomics division, focusing on understanding genomic alterations in cancer and their implications for personalized therapies. The role involves managing a team of researchers and securing external funding for large-scale projects.
  • Key Responsibilities:
    • Develop and lead independent research projects in cancer genomics.
    • Collaborate with international research teams and clinical partners.
    • Mentor PhD students and postdoctoral researchers.
  • Eligibility Requirements:
    • PhD in Genomics, Bioinformatics, or related disciplines.
    • Extensive experience in cancer research and a strong publication record.
    • Proven ability to secure research funding and manage projects.
  • Salary: Competitive, based on experience and qualifications.
  • Application Deadline: Open until filled, with priority given to early applicants.
  • Contact: For informal discussions, please contact Dr. Claus Jorgensen at claus.jorgensen@cruk.manchester.ac.uk.

Why Join CRUK Manchester Institute?

The Cancer Research UK Manchester Institute is a leading centre for cancer research, focusing on fundamental biological processes and their translation into clinical applications. It offers:

  • Cutting-Edge Facilities: Access to next-generation sequencing, mass spectrometry, advanced microscopy, and bioinformatics resources.
  • Collaborative Environment: Opportunities to work with leading researchers in cancer genomics, immunology, and translational research.
  • Supportive Work Culture: The institute promotes equality, diversity, and inclusion, ensuring a welcoming environment for all team members.

How to Apply?

To apply for these positions, complete the online application via the institute’s recruitment portal. Please provide:

  • A cover letter detailing your research interests.
  • An up-to-date CV, including the names of two referees.
  • Applications should be submitted before the specified deadline.

For additional support, contact the HR department at jobs@cruk.manchester.ac.uk.


These roles offer an exciting opportunity to join a dynamic research institute dedicated to understanding cancer biology and developing novel therapeutic strategies. Whether you are a computational biologist, lab manager, or postdoctoral researcher, CRUK MI provides an ideal environment for professional growth and impactful research. Don’t miss your chance to be part of groundbreaking cancer research—apply today!

Stay Updated for PhD Admissions 2025

If you are interested in pursuing a PhD at Cancer Research UK Manchester Institute (CRUK MI), the institute has also opened applications for the 2025 PhD intake. This prestigious program offers a comprehensive research training environment and is fully funded, covering tuition fees, a competitive stipend, and research costs.

For detailed information about the PhD program, eligibility criteria, application deadlines, and how to apply, please follow this link: PhD Admissions at CRUK MI for 2025.

Cancer Research UK Manchester Institute (CRUK MI)
 
Cancer Research UK Manchester Institute (CRUK MI)

For more updates on PhD programs, fellowships, and research opportunities, stay connected with Daily First.

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